The offline DFC systems include a fraction collector or an auto sampler which will collect the sampled dissolution media. The semi-automated DFC-1220SP system is composed of a PTWS 1220 staggered stirrer start dissolution bath with built-in individual vessel centering, full tubing installation in PTFE including either in-situ sampling probes or the EPE-1220 auto sampling system, 2 PT-SP8 syringe pumps, and a PTFC-16 fraction collector. In this configuration the sampling probes are either always immersed into the media (in-situ) or removed after sampling (EPE-1220 system). Both procedures are widely used.

Advantages:
>> The system automates the taking of samples, the most labor intensive stage of a dissolution test
>> Automated sampling eliminates human errors, as equal sampling times and standardized solvent transport offer high reproducibility
>> Excellent reproducibility of sampling volumes and times
>> Offers unattended operation after start of dissolution run
>> Pharma Test offers full system responsibility