The Pharma Test media addition station PTWS 820-MA together with the PTWS 820D tablet dissolution testing instrument can be used to perform the automated media half change for delayed release dosage forms. The operation is performing according to the requirements from USP <711>, EP <2.9.3> and CP <931> for delayed release dosage forms (in CP, enteric coated dosage forms). The test will start with 750ml of 0.1N HCl. After 2 hours, 250ml of concentrated, pre-heated buffer solution will be dosed quickly into the dissolution vessels. The pH will change to 6.8 and the dosage form should then start to dissolve.

Advantages:
>> Very fast buffer adding which corresponds to a pump flowrate of 500ml/min
>> According to USP <711> and EP 2.9.3 the test must be “proceeded immediately” after the 2h in 0,1N HCl
>> Includes an additional heating system which will preheat the buffer in the USP Tolerance of 37 +/-0.5°C
>> No temperature change in the dissolution vessel
>> Unattended operation for the media change